Programme

Final Agenda

Monday 5th June 2017
12:00 - 14:00Registration Open
14:00 - 16:10Session 1: Ubiquitination and the IKK complex
14:00 - 15:00Keynote Lecture
Ubiquitin signals in NF-kB activation
Dr David Komander
15:00 - 15:30The MyD88-dependent regulation of the canonical IKK complex by E3 ligases
Sir Philip Cohen
15:30 - 15:50Ubiquitination of p50 is orchestrated by a complex network of components of the ubiquitin protease system with significant implications in the understanding of the regulation of inflammation
Miss Jennifer Mitchell
15:50 - 16:10IKKbeta regulates activation of the NLRP3 inflammasome by a novel mechanism
Dr Sambit Nanda
16:10 - 16:30Tea & Coffee Break
16:30 - 18:00Session 2: Crosstalk with other pathways
16:30 - 17:00The interplay between the HIF pathway and NK-kappaB in normoxia and hypoxia
Professor Sonia Rocha
17:00 - 17:30The Role of Hypoxia in Immunity and Inflammation
Cormac Taylor
17:30 - 18:00Aspirin, RelA and Proteotoxic stress
Dr Lesley Stark
18:00 - 19:30Welcome Reception & Poster Session
Tuesday 6th June
09:00 - 11:30Session 3: Transcriptional Regulation
09:00 - 10:00Keynote Lecture
Lienhard Schmitz
10:00 - 10:30The regulation of NF-kB by p50 phosphorylation
Dr Ruaidhri Carmody
10:30 - 10:50The structural basis of the anti-inflammatory NF-kB p50:p50:HDAC1 co-repressor complex
Mr Tyrell Cartwright
10:50 - 11:10Quantitative analysis of the effect of NF-kB feedback on target gene expression
Dr David Spiller
11:10 - 12:00Tea & Coffee Break
12:00 - 13:00Session 4: Novel Techniques
12:00 - 12:30DNA binding stabilises the core structure of the NF-kB p50 homodimer
Professor Claire Eyers
12:30 - 13:00Manipulation of NF-kB dynamics
Claire Harper
13:00 - 14:00Lunch
14:00 - 15:45Session 5: NF-kB and Cancer
14:00 - 14:30Targeting inhibitory-kappaB kinase alpha (IKKa) in cancer with small molecule kinase inhibitors
Dr. Andrew Paul
14:30 - 15:00Targeting NK-kB inducing kinase in B-cell malignancies
Professor Chris Pepper
15:00 - 15:30NF-kB regulates the MYC-induced DNA replication stress response in B-cell lymphoma
Dr Jill Hunter
15:30 - 15:50RNA helicase UAP56 and the kB-site in the reponse to DNA damage
Dr Bakhtiar Yamini
15:50 - 16:15Tea & Coffee Break
16:15 - 18:15Session 6: NF-kB and Cancer
16:15 - 16:45The roles of NK-kappaB in both extrinsic and intrinsic mechanisms of immune suppression in cancer
Dr Toby Lawrence
16:45 - 17:15Autophagic regulation of NF-kB and non-canonical IKK responses
Dr Simon Wilkinson
17:15 - 17:35The Role of NK-kB in the Response to Reoxygenation-Induced Oxidative Stress
Dr Niall Kenneth
17:35 - 17:55The relationship between the non-canonical NK-kB pathway, tumour microenvironment, systemic inflammation and survival in patients undergoing surgery for colorectal caner
Dr Meera Patel
17:55 - 19:15Free Time
19:15 - 00:00Conference Dinner & Dance
Wednesday 7th June
09:00 - 10:30Session 7: NF-kB and Inflammation
09:00 - 09:30Mechanical activation of NK-kB drives atherosclerosis initiation at sites of disturbed blood flow
Shuang Feng
09:30 - 10:00The NF-kB subunits NF-kB1, NF-kB2 and c-Rel differentially regulate inflammation and inflammation-associated cancer development in the murine GI tract
Mark Pritchard
10:00 - 10:20cRel is a master regulator of the epithelial - immune cell axis during wound healing and fibrosis
10:20 - 10:40Regulation of Fibroblast Phenotype, Functionality, Extracellular Matrix Production and Cellular Interactions by c-Rel in Dermal Fibrosis
Dr Julie Worrell
10:40 - 11:00Tea & Coffee Break
11:00 - 12:50Session 8: NF-kB and Inflammation
11:00 - 11:30Inflammatory dynamics of the NF-kB regulatory network
Dr Pawel Paszek
11:30 - 11:50Mechanisms of carbon dioxide dependent regulation of NFkB signalling
Ms Ciara E. Keogh
11:50 - 12:10NIK promotes the generation of functional effector T-cells
Ms Sonja Lacher
12:10 - 12:30Molluscum Contagiosum Virus protein MC005 inhibits innate virus sensing and pro-inflammatory cytokine-mediated activation of the IKK complex and NFkB by targeting IKKy/NEMO
Dr Gareth Brady
12:30 - 12:50Assessing the effects of moderate exercise on a mouse model of chronic inflammation
Dr Arianna Bianchi
12:50 - 13:00Closing Remarks
Please note that the agenda may change at any time.